Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce is a delightful dish that combines bold flavors with creamy goodness. Perfect for weeknight dinners or special occasions, this recipe stands out for its rich taste and ease of preparation. With just a few ingredients, you can whip up a satisfying meal that everyone will love, making it an ideal choice for family gatherings or cozy nights in.

Jump to:
- Why You’ll Love This Recipe
- Tools and Preparation
- Essential Tools and Equipment
- Importance of Each Tool
- Ingredients
- For the Beef and Sauce
- For the Pasta
- For the Cheese Sauce
- Final Touches
- How to Make Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Step 1: Cook the Penne Pasta
- Step 2: Sauté Garlic and Beef
- Step 3: Season the Beef
- Step 4: Make the Cheese Sauce
- Step 5: Combine Cheeses
- Step 6: Combine Pasta with Sauce
- Step 7: Final Seasoning
- Step 8: Serve
- How to Serve Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- With Fresh Salad
- Accompanied by Garlic Bread
- Topped with Extra Cheese
- Garnished with Fresh Herbs
- Served with a Side of Steamed Vegetables
- How to Perfect Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Best Side Dishes for Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Common Mistakes to Avoid
- Storage & Reheating Instructions
- Refrigerator Storage
- Freezing Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Reheating Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Frequently Asked Questions
- What can I substitute for heavy cream in Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce?
- How can I customize my Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce?
- Can I make Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce ahead of time?
- What is the calorie count for Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce?
- Final Thoughts
- 📖 Recipe Card
Why You’ll Love This Recipe
- Quick to Prepare: This dish takes only 30 minutes to make, perfect for busy weeknights.
- Rich and Flavorful: The combination of garlic butter and Cajun seasoning creates a mouthwatering flavor profile.
- Creamy Comfort Food: The velvety cheese sauce wraps the penne pasta in warmth and indulgence.
- Versatile Ingredients: You can easily substitute or add your favorite veggies to customize the dish.
- Family-Friendly: A hit with both kids and adults, ensuring everyone leaves the table happy.
Tools and Preparation
To make Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce, you’ll need some essential tools to streamline the cooking process.
Essential Tools and Equipment
- Large pot
- Large skillet
- Cutting board
- Chef’s knife
- Colander
Importance of Each Tool
- Large pot: Essential for boiling the penne pasta until al dente without overcrowding.
- Large skillet: Perfect for sautéing the beef and combining all ingredients into a delicious sauce.
- Cutting board & Chef’s knife: Important for safely preparing your garlic and other ingredients with ease.

Ingredients
For the Beef and Sauce
- 1 lb ground beef
- 2 tablespoons butter
- 4 cloves garlic, minced
- 1 tablespoon Cajun seasoning
- 1 teaspoon Italian seasoning (optional but recommended)
For the Pasta
- 12 oz penne pasta
For the Cheese Sauce
- 1 cup heavy cream
- 1 cup Velveeta cheese, cubed
- 1 cup shredded mozzarella cheese
- cup grated Parmesan cheese
Final Touches
- Salt and black pepper to taste
- Fresh parsley for garnish (optional)
How to Make Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
Step 1: Cook the Penne Pasta
Bring a large pot of salted water to a boil. Cook the penne pasta according to package directions until al dente. Drain and set aside.
Step 2: Sauté Garlic and Beef
In a large skillet over medium heat, melt the butter. Add the minced garlic and sauté for 1 minute until fragrant. Then:
1. Add the ground beef to the skillet.
2. Cook until browned, breaking it up with a spatula.
3. Drain any excess fat from the skillet.
Step 3: Season the Beef
Sprinkle the Cajun seasoning and Italian seasoning over the beef. Stir well to coat the meat with seasonings.
Step 4: Make the Cheese Sauce
Pour in the heavy cream and reduce heat to medium-low. Then:
1. Add the Velveeta cubes.
2. Stir until melted into a smooth sauce.
Step 5: Combine Cheeses
Stir in mozzarella and Parmesan cheeses, mixing until fully melted and thickened into a creamy sauce.
Step 6: Combine Pasta with Sauce
Add cooked penne pasta to the skillet. Toss everything together to ensure pasta is fully coated in cheesy goodness.
Step 7: Final Seasoning
Taste your dish and adjust with salt and pepper as needed. Let it simmer for a couple more minutes if you want it thicker.
Step 8: Serve
Serve hot, garnished with chopped parsley if desired. Enjoy your delicious Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce!
How to Serve Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
Serving Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce is all about presentation and enhancing flavors. This dish is rich and creamy, making it the perfect centerpiece for any meal. Here are some delightful serving suggestions to elevate your dining experience.
With Fresh Salad
- A crisp green salad with mixed greens, cherry tomatoes, and a light vinaigrette pairs beautifully with the creamy pasta.
Accompanied by Garlic Bread
- Crunchy garlic bread adds a nice texture contrast and complements the garlic flavor in the pasta.
Topped with Extra Cheese
- Sprinkle some additional grated Parmesan or mozzarella on top before serving for an extra cheesy indulgence.
Garnished with Fresh Herbs
- Chopped fresh parsley or basil not only adds color but also enhances the aroma of the dish.
Served with a Side of Steamed Vegetables
- Lightly steamed broccoli or green beans provide a healthy balance to the richness of the penne.
How to Perfect Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
To achieve the best results with your Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce, follow these helpful tips for a dish that’s sure to impress.
Use fresh ingredients: Fresh garlic and herbs will enhance the overall flavor of your dish significantly.
Cook pasta al dente: This ensures that your penne maintains its shape and texture when mixed with the creamy sauce.
Adjust seasoning carefully: Taste as you go! Adjusting salt and pepper at different stages helps build layers of flavor.
Let it simmer: Allowing your sauce to simmer for a few minutes helps thicken it and melds all flavors together beautifully.
Customize spice levels: Feel free to adjust the amount of Cajun seasoning based on your spice preference.
Best Side Dishes for Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
Pairing side dishes with Garlic Butter Cajun Beef Penne can enhance your meal even further. Consider these delicious options that complement its rich flavors wonderfully.
Caesar Salad
A classic Caesar salad with crunchy croutons and creamy dressing balances out the richness of the penne.Roasted Asparagus
Lightly seasoned roasted asparagus adds a healthy touch and a nice crunch to your plate.Corn on the Cob
Sweet corn on the cob brings a burst of flavor that contrasts well with the savory pasta dish.Coleslaw
Creamy coleslaw provides a refreshing crunch that works beautifully alongside this hearty meal.Baked Sweet Potatoes
The natural sweetness of baked sweet potatoes pairs nicely with the spiciness of the Cajun beef.Stuffed Bell Peppers
Colorful stuffed bell peppers can add both nutrition and vibrant color to your table setting.
Common Mistakes to Avoid
Cooking can be tricky, and avoiding common mistakes will elevate your Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce.
- Using the wrong pasta: Not all pasta types work well for this dish. Stick with penne for the best texture and sauce adherence.
- Overcooking the beef: Cooking ground beef too long can make it tough. Aim for a nice brown color while keeping it juicy.
- Skipping the seasoning: Cajun seasoning is key to flavor. Don’t skip it; adjust to your taste but ensure it’s present for that authentic kick.
- Not simmering long enough: Allowing the sauce to simmer helps meld flavors. Don’t rush this step; a few extra minutes make a difference.
- Ignoring cheese quality: Using low-quality cheese can affect the sauce’s creaminess. Opt for fresh, good-quality cheeses for the best result.

Storage & Reheating Instructions
Refrigerator Storage
- Store in an airtight container.
- Keep in the refrigerator for up to 3 days.
Freezing Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Use freezer-safe containers or bags.
- Can be frozen for up to 2 months for best flavor.
Reheating Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Oven: Preheat to 350°F (175°C) and cover with foil. Bake until heated through, about 20-25 minutes.
- Microwave: Place in a microwave-safe dish and heat on medium power, stirring occasionally until hot.
- Stovetop: Reheat gently over low heat, adding a splash of milk or broth if needed to loosen up the sauce.
Frequently Asked Questions
Here are some common questions about Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce that might help you get started.
What can I substitute for heavy cream in Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce?
You can use half-and-half or a plant-based cream alternative if you want a lighter version while maintaining creaminess.
How can I customize my Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce?
Feel free to add vegetables like bell peppers or spinach for extra nutrition and flavor.
Can I make Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce ahead of time?
Yes! Prepare the dish ahead of time and store it as directed. Just reheat before serving.
What is the calorie count for Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce?
Each serving contains approximately 760 calories, making it a hearty meal option.
Final Thoughts
Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce is not only delicious but also versatile. You can easily customize it with different vegetables or cheeses based on your preferences. We encourage you to try this recipe at home and enjoy a delightful meal!
Did You Enjoy Making This Recipe? Please rate this recipe with ⭐⭐⭐⭐⭐ or leave a comment.
📖 Recipe Card
Print
Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce
- Total Time: 30 minutes
- Yield: Serves approximately 4 people 1x
Description
Garlic Butter Cajun Beef Penne in Velvety Cheese Sauce is a delectable dish that brings together the bold flavors of Cajun seasoning and the creaminess of cheese, creating a comforting meal perfect for any occasion. This easy-to-make recipe is ready in just 30 minutes, making it ideal for busy weeknights or family gatherings. The combination of garlic butter, tender beef, and al dente penne pasta enveloped in a rich cheese sauce ensures a satisfying experience that will leave everyone at the table happy. Feel free to customize with your favorite vegetables for an extra nutritional boost.
Ingredients
- 1 lb ground beef
- 12 oz penne pasta
- 1 cup heavy cream
- 1 cup Velveeta cheese, cubed
- 1 cup shredded mozzarella cheese
- 4 cloves garlic, minced
- 2 tablespoons butter
- 1 tablespoon Cajun seasoning
- 1 teaspoon Italian seasoning (optional but recommended)
- Salt and black pepper to taste
Instructions
- 1. Cook the penne pasta in a large pot of salted boiling water until al dente. Drain and set aside.
- 2. In a large skillet, melt butter over medium heat and sauté minced garlic until fragrant.
- 3. Add ground beef to the skillet and cook until browned, breaking it up as needed. Drain excess fat.
- 4. Season the beef with Cajun seasoning and stir to combine.
- 5. Pour in heavy cream and reduce heat; add Velveeta cheese cubes, stirring until melted and smooth.
- 6. Mix in mozzarella and Parmesan cheeses until fully melted.
- 7. Add cooked penne to the sauce, tossing to coat evenly.
- 8. Season with salt and pepper, simmer briefly if desired for thickness, then serve hot.
- Prep Time: 10 minutes
- Cook Time: 20 minutes
- Category: Main
- Method: Stovetop
- Cuisine: American
Nutrition
- Serving Size: 1 serving
- Calories: 760
- Sugar: 4g
- Sodium: 850mg
- Fat: 48g
- Saturated Fat: 24g
- Unsaturated Fat: 20g
- Trans Fat: 0g
- Carbohydrates: 53g
- Fiber: 2g
- Protein: 34g
- Cholesterol: 130mg